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A cohort of 50 patientswith early-onset IAVO in whom 33 patients had staphylococcal infection was reported in2012 [44]. In addition, the client’s sister is obese andhas Graves’ disease and hypercholesterolemia. These patients haverisk factors for cerebrovascular disease and have evidenceof multiple vascular insults in the basal ganglia or whitematter on neuroimaging studies or at autopsy

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Peripheral neuritis and a variety ofneurological manifestations (paresthesias, numb-ness, mental disturbances, rarely convulsions)are the most important dose-dependent toxiceffects.

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