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Chandler DS, Singh RK, Caldwell LC, Bitler JL, Lozano G (2006) Genotoxic stress inducescoordinately regulated alternative splicing of the p53 modulators MDM2 and MDM4. (1995) suggest that a woman being told that theparalysed husband she is caring for will not recover might become depressed, but another, able toleave her violent or feckless partner, may feel liberated

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Manufacturer’s packageinserts should be consulted while coprescribingany other drug. It is ideal to monitor blood gasanalysis to ensure PaCO2 is within optimal range (32–38mmHg); however, it is oftenmore practical to monitor EtCO2

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